Journal: medRxiv

Article Title: A 3’UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP

doi: 10.1101/2023.07.06.23292312

Figure Lengend Snippet: Effect of rs1990622 as a TMEM106B expression quantitative trait locus (eQTL) or protein quantitative trait locus (pQTL). All effect sizes are reported for the tested A allele with the G allele set as reference at rs1990622. Parameter estimates are those reported by respective studies and may be on different scales given different normalization procedures for transcriptomic and proteomic data.

Article Snippet: In a smaller brain eQTL dataset (African ancestry - Metabrain; n=1,016), rs1990622(A) was significantly associated with increased TMEM106B expression.

Techniques: Expressing, Clinical Proteomics

Journal: Acta Neuropathologica

Article Title: Targeting fibroblast growth factor receptors to combat aggressive ependymoma

doi: 10.1007/s00401-021-02327-x

Figure Lengend Snippet: FGFR expression of cell populations during brain development. a Expression of FGFR1 and FGFR3 mRNA in diverse stages of mouse brain development as indicated. In situ hybridization data was derived from the Allen Developing Mouse Brain Atlas (Copyright Allen Institute for Brain Science, http://developingmouse.brain-map.org ). Blue arrows indicate the subventricular zone. b Single-cell mRNA expression of FGFR1 and FGFR3 in diverse cell populations within the developing mouse brain. Data was generously provided by Sten Linnarsson and adapted from www.mousebrain.org . Expression levels are indicated by color (yellow = low; red = intermediate; black = high)

Article Snippet: In situ hybridization data was obtained from the Allen Developing Mouse Brain Atlas (Copyright Allen Institute for Brain Science, http://developingmouse.brain-map.org ).

Techniques: Expressing, In Situ Hybridization, Derivative Assay